Spider-Man: House of M

This five part limited series is of course part of the giant House of M alternate universe extravaganza. Spider-Man in this world is a hugely popular celebrity, who suffers a dramatic reversal of fortunes when the news is leaked that he is not in fact a mutant. (Remember that in this universe, non-mutants are second-class citizens). The story is mostly independant from the main House of M plot-line, and of course it's alternate universe, so you could ignore it entirely. But it's actually pretty decent stuff, so maybe go check it out just to be sure.

  Spider-Man: House of M #1
Editor: Tom Brevoort
Writer: Mark Waid, Tom Peyer
Pencils: Salvador Larroca
Inker: Danny Miki
Variant San Diego Comic Con Wizard World Chicago "Sketch" Cover
  Spider-Man: House of M #2
Review:     [3 Webs] by Joey Andrade
Editor: Tom Brevoort
Writer: Mark Waid, Tom Peyer
Pencils: Salvador Larroca
Inker: Danny Miki
Variant Edition
  Spider-Man: House of M #3
  Spider-Man: House of M #4
  Spider-Man: House of M #5