Secret Invasion: Fantastic Four

 Continuity: Earth-616 (Mainstream)
 Title Base: No Spider-Man

Ben Grimm; his best friend, Reed Richards, AKA Mr. Fantastic; Reed's wife, Sue Storm; her brother Johnny Storm: these are the members of the famed Fantastic Four... but are they who they appear to be? The mysterious alien shape-shifters, the Skrulls, have secretly infiltrated Marvel's First Family of Superheroes.

Whom, precisely, can you trust?

  Secret Invasion: Fantastic Four #1
Story: “Negative Energy”
Summary: Spider-Man reference
Arc: Part 1 of 'No One Gets Back Alive!' (1-2)
  Secret Invasion: Fantastic Four #2
Story: “He's Just Not That Into You”
Arc: Part 2 of 'No One Gets Back Alive!' (1-2)
  Secret Invasion: Fantastic Four #3
Story: “Escape from Fantasy Island”
Summary: No Spider-Man
 Continuity: Earth-616 (Mainstream)
 Title Base: No Spider-Man