4

 Continuity: Earth-616 (Mainstream)
 Title Base: No Spider-Man

This Fantastic Four series started in 2004 and was published under Marvel's Marvel Knights banner.

  4 #30
Review:  No Review Yet
Story: “Open House”
Summary: Spider-Man cameo (waving in crowd)
Editor: Warren Simons
Writer: Roberto Aguirre-Sacasa
Pencils: Clay Mann
Inker: Jon Sibal
 Continuity: Earth-616 (Mainstream)
 Title Base: No Spider-Man