Spider-Man teams up with Daredevil to stop the invading forces of Hydra from taking over new York. The game contains six levels which contain hydra agents and all sorts of robots. Each level has its bosses, some more than one. They consist of Dragonman, Thermite, Blitz, The Vanisher, Eel, Tangle, and the Super-adaptoid.
Very similar to the preceding Spider-Man vs. the Kingpin, with different characters, improved graphics, but less interesting. Not very successful, and rather hard to find (like the Sega Genesis 32X platform which ran it).